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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HLTF
All Species:
22.12
Human Site:
T669
Identified Species:
37.44
UniProt:
Q14527
Number Species:
13
Phosphosite Substitution
Charge Score:
0.31
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14527
NP_003062.2
1009
113929
T669
K
V
F
I
Q
H
I
T
L
S
D
E
E
R
K
Chimpanzee
Pan troglodytes
XP_001138277
1009
113822
T669
K
V
F
I
Q
H
I
T
L
S
D
E
E
R
K
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_534300
1106
124184
T766
K
V
F
I
Q
H
I
T
L
S
D
E
E
R
K
Cat
Felis silvestris
Mouse
Mus musculus
Q6PCN7
1003
113298
T663
K
V
F
I
Q
H
I
T
L
S
E
E
E
R
K
Rat
Rattus norvegicus
NP_001099948
974
110023
T634
K
V
F
I
Q
H
I
T
L
S
V
E
E
R
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508504
884
99044
D610
S
S
A
P
S
G
N
D
T
P
E
E
L
R
K
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001090145
999
112576
E659
K
V
F
I
Q
H
V
E
L
S
E
E
E
R
E
Zebra Danio
Brachydanio rerio
XP_693071
942
104740
F638
R
Y
F
Q
E
G
T
F
M
A
N
Y
A
D
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P34739
1061
118357
S711
E
L
R
L
I
E
I
S
L
D
K
E
E
M
N
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_786706
1093
121576
D747
N
V
V
L
Q
Y
V
D
F
S
E
D
E
K
K
Poplar Tree
Populus trichocarpa
XP_002308876
799
88908
L525
P
S
D
L
R
S
L
L
P
S
N
S
I
E
D
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FF61
881
98598
S607
E
L
R
S
F
T
T
S
T
S
V
E
D
V
T
Baker's Yeast
Sacchar. cerevisiae
P31244
790
91412
H516
R
M
R
Q
L
A
D
H
P
D
L
V
L
K
R
Red Bread Mold
Neurospora crassa
Q7S1P9
1222
137173
E843
H
I
E
I
V
D
I
E
L
S
E
P
E
R
A
Conservation
Percent
Protein Identity:
100
99.5
N.A.
85.5
N.A.
83.6
81.4
N.A.
71.7
N.A.
64.3
53.1
N.A.
21.1
N.A.
N.A.
34.5
Protein Similarity:
100
99.8
N.A.
88
N.A.
89.7
87.9
N.A.
78.5
N.A.
79.3
69.8
N.A.
41.2
N.A.
N.A.
53.1
P-Site Identity:
100
100
N.A.
100
N.A.
93.3
93.3
N.A.
20
N.A.
73.3
6.6
N.A.
26.6
N.A.
N.A.
33.3
P-Site Similarity:
100
100
N.A.
100
N.A.
100
93.3
N.A.
26.6
N.A.
93.3
40
N.A.
53.3
N.A.
N.A.
73.3
Percent
Protein Identity:
33.6
N.A.
N.A.
36
22.7
25.2
Protein Similarity:
50.4
N.A.
N.A.
52.7
40.9
43.9
P-Site Identity:
6.6
N.A.
N.A.
13.3
0
40
P-Site Similarity:
33.3
N.A.
N.A.
40
26.6
53.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
0
0
8
0
0
0
8
0
0
8
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
8
0
0
8
8
15
0
15
22
8
8
8
8
% D
% Glu:
15
0
8
0
8
8
0
15
0
0
36
65
65
8
8
% E
% Phe:
0
0
50
0
8
0
0
8
8
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
15
0
0
0
0
0
0
0
0
0
% G
% His:
8
0
0
0
0
43
0
8
0
0
0
0
0
0
0
% H
% Ile:
0
8
0
50
8
0
50
0
0
0
0
0
8
0
0
% I
% Lys:
43
0
0
0
0
0
0
0
0
0
8
0
0
15
50
% K
% Leu:
0
15
0
22
8
0
8
8
58
0
8
0
15
0
0
% L
% Met:
0
8
0
0
0
0
0
0
8
0
0
0
0
8
0
% M
% Asn:
8
0
0
0
0
0
8
0
0
0
15
0
0
0
8
% N
% Pro:
8
0
0
8
0
0
0
0
15
8
0
8
0
0
0
% P
% Gln:
0
0
0
15
50
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
15
0
22
0
8
0
0
0
0
0
0
0
0
58
8
% R
% Ser:
8
15
0
8
8
8
0
15
0
72
0
8
0
0
0
% S
% Thr:
0
0
0
0
0
8
15
36
15
0
0
0
0
0
8
% T
% Val:
0
50
8
0
8
0
15
0
0
0
15
8
0
8
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
0
0
8
0
0
0
0
0
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _